Synthesis of Biologically Active Molecules through Multicomponent Reactions

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

synthesis of phosphorus derivatives via multicomponent reactions

Mass Spectrometry of Biologically Active Small Molecules

The main foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols, alkaloids and amino acids published in five appended studies are presented and discussed. Various MS methods were applie...

Multicomponent reactions for the synthesis of pyrroles.

Multicomponent reactions are one of the most interesting concepts in modern synthetic chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole derivatives, which are very important heterocycles from many points of view including medicinal and pharmaceutical chemistry and materials science (97 references).

Synthesis of Biologically Active -Aminophosphonates

Abstract: Highly convergent Synthesis of -aminophosphonates were most conveniently achieved using organophosphorus chemistry. Synthesis of -aminophosphonates were accomplished by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These aminophosphonates exhibited promising antimicrobial, antioxidant and anticancer activity. Some recent developments and applications to th...